Sodium Inactivation
نویسندگان
چکیده
منابع مشابه
Mechanisms of sodium channel inactivation.
Rapid inactivation of sodium channels is crucial for the normal electrical activity of excitable cells. There are many different types of inactivation, including fast, slow and ultra-slow, and each of these can be modulated by cellular factors or accessory subunits. Fast inactivation occurs by a 'hinged lid' mechanism in which an inactivating particle occludes the pore, whereas slow inactivatio...
متن کاملInactivation of the Sodium Channel
A B S X R A C T Gating current (I~) has been studied in relation to inactivation of the Na channels. No component of lg has the time course of inactivation; apparent ly little or no charge movement is associated with this step. Inactivation nonetheless affects Ig by immobilizing about two-thirds of gating charge. Immobilization can be followed by measuring ON charge movement dur ing a pulse and...
متن کاملInactivation of the Sodium Channel
A B S X R A C T Gating current (I~) has been studied in relation to inactivation of the Na channels. No component of lg has the time course of inactivation; apparent ly little or no charge movement is associated with this step. Inactivation nonetheless affects Ig by immobilizing about two-thirds of gating charge. Immobilization can be followed by measuring ON charge movement dur ing a pulse and...
متن کاملInactivation of the Sodium Channel
A B S X R A C T Gating current (I~) has been studied in relation to inactivation of the Na channels. No component of lg has the time course of inactivation; apparent ly little or no charge movement is associated with this step. Inactivation nonetheless affects Ig by immobilizing about two-thirds of gating charge. Immobilization can be followed by measuring ON charge movement dur ing a pulse and...
متن کاملInactivation of the Sodium Channel
A B S X R A C T Gating current (I~) has been studied in relation to inactivation of the Na channels. No component of lg has the time course of inactivation; apparent ly little or no charge movement is associated with this step. Inactivation nonetheless affects Ig by immobilizing about two-thirds of gating charge. Immobilization can be followed by measuring ON charge movement dur ing a pulse and...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1970
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(70)86323-8